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The difference in the mean values
2024-02-19

The difference in the mean values of serum ADA in sputum positive PTB and controls was found to be highly significant (P significant in both smear positive and smear negative patients at the end of follow up at 2 months (P Discussion Tuberculosis is a major health problem in India, and out of all
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Curcumin is the principal natural polyphenol curcuminoid of
2024-02-19

Curcumin is the principal natural polyphenol curcuminoid of turmeric (Curcuma longa) rhizome, a member of the ginger family (Zingiberaceae) [13]. Curcumin has a wide spectrum of therapeutic properties, and it has been shown to possess antioxidant, anti-inflammatory, anticancer, antiangiogenesis, che
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Introduction Chronic inflammation is increasingly
2024-02-19

Introduction Chronic inflammation is increasingly known as one of the most critical etiological factors in gastrointestinal (GI) cancers (Lee et al., 2016; Wang and Cho, 2015). Overexpression of 5-lipoxygenase (5-LOX), 5-LOX-activating protein (FLAP), as well as other leukotriene (LT) biosynthetic
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br Conclusion br Acknowledgement This study was supported
2024-02-19

Conclusion Acknowledgement This study was supported by NIH/NINDSR01 NS036812-16. Introduction Stroke is the leading cause of disability and the fifth leading cause of death in the United States (Writing Group et al., 2016). On average, every 4 min a human dies of stroke (Lackland et al., 2
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Two parallel branches of the DNA damage dependent S phase
2024-02-19

Two parallel branches of the DNA damage-dependent S-phase checkpoint are thought to co-operate by inhibiting distinct steps of DNA replication. One branch includes the phosphorylation of structural maintenance of chromosomes 1 (SMC1), a cohesin that is activated by ATM or ATR after IR treatment or r
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The fluorescence in a fluorescent antibiotic can
2024-02-19

The fluorescence in a fluorescent antibiotic can be derived either from functional groups with intrinsic fluorescence in an existing antibiotic, or via synthetic conjugation of a fluorophore to an antibiotic core to enable visualisation. Attachment of fluorophore to an antibiotic should ideally not
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A phase I trial has recently evaluated
2024-02-18

A phase I trial has recently evaluated enzalutamide, an anti-androgen agent, in patients with ER- and AR-positive advanced BC to estimate safety and tolerability of enzalutamide therapy alone or in association to anastrozole, exemestane or fulvestrant [65]. The results of major clinical trials with
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br Material and methods br Results br Discussion Nimodipine
2024-02-18

Material and methods Results Discussion Nimodipine administration inhibited the level of AMP-activated protein kinase (AMPK) phosphorylation, a sensor of cellular energy status that directs metabolic Tobramycin to support cellular growth and survival. CCH influences the oxygen and glucose
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br Materials and methods br Results br Discussion The
2024-02-18

Materials and methods Results Discussion The novel and central finding of the current study is that endothelial 12/15-LO rather than the monocytic/macrophagic 12/15-LO has a critical role in hyperglycemia-induced leukocyte adhesion and retinal endothelial barrier dysfunction. The following
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The Limitations of our data include the absence of functiona
2024-02-10

The Limitations of our data include the absence of functional/behavioral assessments and lack of direct comparison with females which would require additional studies and conceivably support sex-specific interventions for stroke [50]. Competing interests Acknowledgements This study was suppor
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br Materials and methods br Results br Discussion Our
2024-02-09

Materials and methods Results Discussion Our results revealed that LPS injection in rats impaired fear memory in the PA task. This results are in agreement with the most of previous studies reported that following acute [23,24,39,[45], [46], [47]] or chronic systemic STAT5 Inhibitor mg [30
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2×Taq PCR Master Mix(with dye) Similarly compound was p
2024-02-09

Similarly, 2×Taq PCR Master Mix(with dye) 13 was prepared from aldehyde 8d by following similar procedures (Scheme 3). Condensation of 13 with 7b or 7e provided the corresponding amides 9j or 9k, which then went through O-debenzylation by BCl3 to deliver the final compounds 10j and 10k in 37% and 3
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Nuclear/Cytosol Fractionation Kit br Introduction Alcohol i
2024-02-09

Introduction Alcohol, i.e., ethanol, is absorbed into the blood from the stomach to the small intestine, then distributed throughout the body. The metabolism of alcohol converting to acetic Nuclear/Cytosol Fractionation Kit basically involves two enzymes; alcohol dehydrogenase converting ethanol
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br Hypothesis The hypothesis is that AhR in
2024-02-09

Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un
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br Theoretical mechanism of ABCA activity in LE
2024-02-09

Theoretical mechanism of ABCA2 activity in LE/LY in modulation of cholesterol trafficking It is important to confirm that ABCA2 is a lipid transporter and identify the substrates that are mechanistic in its cholesterol sequestering activity. We hypothesize that ABCA2 modulates cholesterol sequest
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