• br Introduction It has become

  2020-08-04

  

  Introduction It has become increasingly apparent that seemingly identical cells in a population can actually be a heterogenous mixture differing at genome, transcriptome, and/or proteome levels. Analysis of this heterogeneity among cells within a population is critical to provide deeper understan

• In the iTRAQ application protocol

  2020-08-04

  

  In the iTRAQ application protocol (Applied Biosystems), labelling of protein digests with the iTRAQ™ Reagents is recommended for 1h at room temperature. However, peptides with partially and fully labelled iTRAQ were identified in the samples of GE digested both at 50°C and 37°C, i.e., αs1-casein f71

• With these results it is now important

  2020-08-04

  

  With these results, it is now important to predict whether a similar response could be obtained in humans immunized with the same E1 sequences. Thus, we used the same analysis criteria to predict peptides for HLA-A2, which is the largest and most diverse allele family in humans [47]. This revealed t

• DbH activity was followed by oxymetry and we

  2020-08-04

  

  DbH activity was followed by oxymetry, and we showed that tyramine was responsible for a partial protection from H2O2-mediated inactivation. Since a peroxo-copper AGN 194310 mg could form, samples of DbH incubated with H2O2 and tyramine were probed for activity by HPLC, but octopamine could only be

• br Conclusion A combination of two computational techniques

  2020-08-04

  

  Conclusion A combination of two computational techniques were applied to study a series of nineteen 7,8-dialkylpyrrolo-[3,2-f] Quinazoline derivatives, not only to generate highly statistical and predictive 3D-QSAR models, but to explore the interaction mechanism between the Quinazoline derivativ

• With regard to neuroticism anxiety

  2020-08-03

  

  With regard to neuroticism/anxiety we did not find any direct associations with conditioned fear responses, which converges with a series of previous studies (Fredrikson and Georgiades, 1992, Grillon et al., 2006, Joos et al., 2012, Lommen et al., 2010, Martínez et al., 2012, Otto et al., 2007, Pine

• br Abbreviations br Acknowledgements br Introduction Dopamin

  2020-08-03

  

  Abbreviations Acknowledgements Introduction Dopamine β-hydroxylase (DbH) is the enzyme catalysing the conversion of dopamine to norepinephrine, two important neurotransmitters involved in the central nervous system [1]. This enzyme has been isolated from bovine chromaffin granules as a tetr

• To our knowledge immunohistochemical analysis for proGRP was

  2020-08-03

  

  To our knowledge, immunohistochemical analysis for proGRP was done in 5 cases [9], [10], [17], [18]. Takagi-Takahashi et al. reported that the tumor s3i were positive for proGRP in one case [9]. Yamaguchi et al. also showed that tumor cells in two patients of ES/PNET with elevated serum proGRP were

• The mechanisms by which Cav enhances embryonal

  2020-08-03

  

  The mechanisms by which Cav-1 enhances embryonal tumor progression are currently unknown. Given the documented ability of Cav-1 to drive increased biogenesis of caveolae and accelerate the flow of nutrients (mostly glucose and fatty acids) across the membrane, as observed in particular in adipocytes

• Cy3 TSA br Methods and materials br Results

  2020-08-03

  

  Methods and materials Results Discussion This study showed that ER-redox disturbance-associated ER stress is linked to cytoplasmic chaperone signaling, including HSP90 stability and its client protein, eNOS. The highly increased PERK and IRE-1α lead to dissociation with the chaperone protei

• On hospital admission her physical examination was

  2020-08-01

  

  On hospital admission, her physical examination was unremarkable except for hepatosplenomegaly, LUQ tenderness, and a non-tender bruise on left thigh. Importantly, no pharyngitis or adenopathy was present. Admission laboratory tests included a white blood cell (WBC) count of 9.8 K/uL (n = 3.9–11 K/u

• The genetic basis of non FH is

  2020-08-01

  

  The genetic basis of non-FH is a relevant and controversial issue. In two different whole exome sequencing in ADH patients negative for LDLR/APOB/PCSK9 mutations [26] and individuals selected for extreme LDL cholesterol (>98th percentile) [27] no major novel locus for FH was detected. A new locus at

• (-)-Bicuculline methiodide synthesis Explaining these result

  2020-07-31

  

  Explaining these results was a major challenge. Many hypotheses were investigated [26]. Finally, the (-)-Bicuculline methiodide synthesis of a post-translational modification was retained as explained below. Actually, after cloning the cDNA in bacteria we produced a protein of 42kDa with an anti-pr

• br Results br Discussion Despite nearly two

  2020-07-31

  

  Results Discussion Despite nearly two decades of investigations, the functional role of collagen X deposition in the growth plate ECM remains ill-defined. Collagen X null-mutation studies have provided support to the notion that the collagen X network is important in maintaining the compositio

• A structural model for the unprecedented interactions betwee

  2020-07-31

  

  A structural model for the unprecedented interactions between UBE2S, its target (i.e., a Ub that has been linked already to an APC/C substrate), and APC/C was generated by hybrid structural studies merging information from NMR, crosslinking, and mutational data with a low-resolution cryo-EM map of A

15455 records 793/1031 page Previous Next First page 上5页 791792793794795 下5页 Last page